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Literature summary extracted from

  • Geiger, R.; Gautschi, M.; Thor, F.; Hayer, A.; Helenius, A.
    Folding, quality control, and secretion of pancreatic ribonuclease in live cells (2011), J. Biol. Chem., 286, 5813-5822.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.18 RNase expression in CHO cells Homo sapiens
4.6.1.18 RNase expression in CHO cells Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.18 N113S the mutant N113S is more prominent in the Golgi than wild-type bovine RNase, which is mainly present in the endoplasmic reticulum Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.18 extracellular the enzyme is secreted Homo sapiens
-
-
4.6.1.18 extracellular the enzyme is secreted Bos taurus
-
-
4.6.1.18 additional information analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. Human RNase folds rapidly and is secreted mainly in glycosylated forms Homo sapiens
-
-
4.6.1.18 additional information analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. In contrast to the slow in vitro refolding, the protein folds almost instantly after translation and translocation into the endoplasmatic reticulum lumen. Despite high stability of the native protein, only about half of the RNase reaches a secretion competent, monomeric form and is rapidly transported from the rough endoplasmic reticulum via the Golgi complex to the extracellular space, the rest remains in the endoplasmic reticulum mainly in the form of dimers and is slowly degraded Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus
-
-
-
4.6.1.18 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.6.1.18 glycoprotein presence of N-glycans, one sequon for N-linked glycosylation Bos taurus
4.6.1.18 glycoprotein presence of N-glycans, three sequons for N-linked glycosylation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 pancreas
-
 Homo sapiens
-
4.6.1.18 pancreas
-
 Bos taurus
-

Subunits

EC Number Subunits Comment Organism
4.6.1.18 monomer
-
 Bos taurus
4.6.1.18 More the secreted RNase in the bovine pancreas is mainly monomeric, whereas the enzyme present in the cells also contains 20% dimers Bos taurus

Synonyms

EC Number Synonyms Comment Organism
4.6.1.18 pancreatic RNase
-
 Homo sapiens
4.6.1.18 pancreatic RNase
-
 Bos taurus

General Information

EC Number General Information Comment Organism
4.6.1.18 additional information analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. Human RNase folds rapidly and is secreted mainly in glycosylated forms Homo sapiens
4.6.1.18 additional information analysis of synthesis and maturation, folding, quality control, and secretion, of pancreatic RNase in the endoplasmic reticulum of live cells, overview. In contrast to the slow in vitro refolding, the protein folds almost instantly after translation and translocation into the endoplasmatic reticulum lumen. Despite high stability of the native protein, only about half of the RNase reaches a secretion competent, monomeric form and is rapidly transported from the rough endoplasmic reticulum via the Golgi complex to the extracellular space Bos taurus